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Article

Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue.

Translational psychiatry - 27 Apr 2021

Patel Devanshi, Zhang Xiaoling, Farrell John J, Chung Jaeyoon, Stein Thor D, Lunetta Kathryn L, Farrer Lindsay A

Abstract excerpt

Because regulation of gene expression is heritable and context-dependent, we investigated AD-related gene expression patterns in cell types in blood and brain. Cis-expression quantitative trait locus (eQTL) mapping was performed genome-wide in blood from 5257 Framingham Heart Study (FHS) participants and in brain donated by 475 Religious Orders Study/Memory & Aging Project (ROSMAP) participants. The association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33907181
DOI: 10.1038/s41398-021-01373-z
PMCID: PMC8079392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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