Back to search

Article

Cell-type Specific Expression Quantitative Trait Loci Associated with Alzheimer Disease in Blood and Brain Tissue

2020-11-24

Abstract excerpt

<h4>ABSTRACT</h4> Because regulation of gene expression is heritable and context-dependent, we investigated AD-related gene expression patterns in cell-types in blood and brain. Cis-expression quantitative trait locus (eQTL) mapping was performed genome-wide in blood from 5,257 Framingham Heart Study (FHS) participants and in brain donated by 475 Religious Orders Study/Memory & Aging Project (ROSMAP) participants....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
48c6343c-202f-5a97-96c1-375ead6a627d
DOI
10.1101/2020.11.23.20237008
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cell-type Specific Expression Quantitative Trait Loci Associated with Alzheimer Disease in Blood and Brain TissueDOI 10.1101/2020.11.23.20237008
Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue.Semantic proximity
Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants.Semantic proximity
Identification of common molecular biomarker signatures in blood and brain of Alzheimer’s diseaseSemantic proximity
Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s diseaseSemantic proximity
Allele-specific analysis reveals exon- and cell-type-specific regulatory effects of Alzheimer's disease-associated genetic variants.Semantic proximity
Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer’s DiseaseSemantic proximity
A transcriptome-wide association study identifies novel blood-based gene biomarker candidates for Alzheimer's disease risk.Semantic proximity
Genomic partitioning of Alzheimer’s disease in humans reveals non-CNS etiologySemantic proximity
Cell-type specific cis-eQTLs in eight brain cell-types identifies novel risk genes for human brain disordersSemantic proximity
Blood Genome-Wide Transcriptional Profiles Reflect Broad Molecular Impairments and Strong Blood-Brain Links in Alzheimer's DiseaseSemantic proximity
Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease.Semantic proximity
Multi-Tissue Neocortical Transcriptome-Wide Association Study Implicates 8 Genes Across 6 Genomic Loci in Alzheimer’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.