Article
Binary outcomes of enhancer activity underlie stable random monoallelic expression.
eLife - 26 May 2022
Kissiov Djem U, Ethell Alexander, Chen Sean, Wolf Natalie K, Zhang Chenyu, Dang Susanna M, Jo Yeara, Madsen Katrine N, Paranjpe Ishan, Lee Angus Y, Chim Bryan, Muljo Stefan A, Raulet David H
Abstract excerpt
Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural killer (NK) cell receptor gene expression and enhancer deletions in the mouse germline. Enhancers of the RME NK receptor genes were accessible and enriched in H3K27ac on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.