Article
Chromatin Signature Identifies Monoallelic Gene Expression Across Mammalian Cell Types.
G3 (Bethesda, Md.) - 18 Jun 2015
Nag Anwesha, Vigneau Sébastien, Savova Virginia, Zwemer Lillian M, Gimelbrant Alexander A
Abstract excerpt
Monoallelic expression of autosomal genes (MAE) is a widespread epigenetic phenomenon which is poorly understood, due in part to current limitations of genome-wide approaches for assessing it. Recently, we reported that a specific histone modification signature is strongly associated with MAE and demonstrated that it can serve as a proxy of MAE in human lymphoblastoid cells. Here, we use murine cells to establish...
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