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Article

Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells.

Nature genetics - 1 Mar 2017

Xu Jin, Carter Ava C, Gendrel Anne-Valerie, Attia Mikael, Loftus Joshua, Greenleaf William J, Tibshirani Robert, Heard Edith, Chang Howard Y

Abstract excerpt

We developed an allele-specific assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) to genotype and profile active regulatory DNA across the genome. Using a mouse hybrid F1 system, we found that monoallelic DNA accessibility across autosomes was pervasive, developmentally programmed and composed of several patterns. Genetically determined accessibility was enriched at distal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28112738
DOI: 10.1038/ng.3769
PMCID: PMC5357084

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