Random monoallelic expression: regulating gene expression one allele at a time.

Abstract excerpt

Monoallelic gene expression is a remarkable process in which transcription occurs from only one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of autosomal genes exhibit random monoallelic gene expression, in which different cells express only one allele independently of the underlying genomic sequence, in a cell type-specific manner. Recently, genome-wide studies have increased...

Topics

• Alleles
• Animals
• Epigenesis, Genetic
• Gene Expression
• Gene Expression Regulation
• Genome
• Genome-Wide Association Study
• Humans