Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Micropillar-based phenotypic screening platform uncovers involvement of HDAC2 in nuclear deformability.

Biomaterials - 1 Jul 2022

Martewicz Sebastian, Zhu Xi, Qu Siqi, Cui Meihua, Grespan Eleonora, Luni Camilla, Jiang Biao, Yang Guang, Elvassore Nicola

Abstract excerpt

Nuclear deformation is an essential phenomenon allowing cell migration and can be observed in association with pathological conditions such as laminopathies, neurodegenerative disorders and diabetes. Abnormal nuclear morphologies are a hallmark of cancer progression and nuclear deformability is a necessary feature for metastatic progression. Nevertheless, the cellular processes and the key molecular components...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phenotype

Source

Identifiers

PMID: 35576810
DOI: 10.1016/j.biomaterials.2022.121564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Micropillar-based phenotypic screening platform uncovers involvement of HDAC2 in nuclear deformability.PMID 35576810Read ↗

Chromatin Reprogramming via Contact Guidance-Induced Nuclear Deformation Promotes Stem Cell DifferentiationSemantic proximity Read ↗

Identification of epigenetic modulators as determinants of nuclear size and shapeSemantic proximity Read ↗

Chromatin histone modifications and rigidity affect nuclear morphology independent of laminsSemantic proximity Read ↗

Microgroove substrates unveil topography-driven, dynamic 3D nuclear deformationsSemantic proximity Read ↗

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution ImagingSemantic proximity Read ↗

Micropatterned substrates to promote and dissect reprogramming of human somatic cellsSemantic proximity Read ↗

Nuclear Mechanopathology and Cancer Diagnosis.Semantic proximity Read ↗

[Advances in cell nuclear mechanobiology and its regulation mechanisms].Semantic proximity Read ↗

Cell shapes decode molecular phenotypes in image-based spatial proteomicsSemantic proximity Read ↗

Micropillar-induced changes in cell nucleus morphology enhance bone regeneration by modulating the secretomeSemantic proximity Read ↗

Manipulation of the nucleoscaffold potentiates cellular reprogramming kineticsSemantic proximity Read ↗

High-throughput cell mechanical phenotyping for label-free titration assays of cytoskeletal modifications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.