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Article

Nuclear Mechanopathology and Cancer Diagnosis.

Trends in cancer - 1 Apr 2018

Uhler Caroline, Shivashankar G V

Abstract excerpt

Abnormalities in nuclear and chromatin organization are hallmarks of many diseases including cancer. In this review, we highlight our understanding of how the cellular microenvironment regulates nuclear morphology and, with it, the spatial organization of chromosomes and genes, resulting in cell type-specific genomic programs. We also discuss the molecular basis for maintaining nuclear and genomic integrity and...

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Identifiers

PMID: 29606315
DOI: 10.1016/j.trecan.2018.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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