Article

Microgroove substrates unveil topography-driven, dynamic 3D nuclear deformations

2024-02-04

Abstract excerpt

Navigating complex extracellular environments requires extensive deformation of cells and their nuclei. Nuclear deformations are intricately linked to nuclear structure and mechanical properties, and abnormalities in nuclear mechanics contribute to various diseases including laminopathies and cancer. Most in vitro systems used to study nuclear deformations are typically designed to generate strong whole-cell conf...

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Identifiers and source

Literature Corpus work: a721260f-3b54-52f2-8fd0-ff6ef1fc562d
DOI: 10.1101/2024.02.02.578638

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