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Article

A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation.

International journal of molecular sciences - 29 Apr 2022

Mattorre Benedetta, Caristi Silvana, Donato Simona, Volpe Emilia, Faiella Marika, Paiardini Alessandro, Sorrentino Rosa, Paladini Fabiana

Abstract excerpt

The M1 zinc metalloproteases ERAP1, ERAP2, and IRAP play a role in HLA-I antigen presentation by refining the peptidome either in the ER (ERAP1 and ERAP2) or in the endosomes (IRAP). They have also been entrusted with other, although less defined, functions such as the regulation of the angiotensin system and blood pressure. In humans, ERAP1 and IRAP are commonly expressed. ERAP2 instead has evolved under...

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Identifiers

PMID: 35563348
DOI: 10.3390/ijms23094961
PMCID: PMC9101739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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