Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.

Molecular immunology - 1 Jan 2014

Alvarez-Navarro Carlos, López de Castro José A

Abstract excerpt

The endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in the final processing of Major Histocompatibility Complex class I (MHC-I) ligands and with a significant influence in the stability and immunological properties of MHC-I proteins. ERAP1 polymorphism is associated with ankylosing spondylitis among HLA-B27-positive individuals and the altered enzymatic activity of natural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases
Share to Endoplasmic Reticulum
Share to Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-B27 Antigen

Share to Macrophage Activation

Share to Minor Histocompatibility Antigens

Share to Neovascularization, Physiologic

Share to Spondylitis, Ankylosing

Source

Identifiers

PMID: 23916068
DOI: 10.1016/j.molimm.2013.06.012

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.PMID 23916068Read ↗

ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role.Semantic proximity Read ↗

ERAP1 and ankylosing spondylitis.Semantic proximity Read ↗

ERAP1 in the pathogenesis of ankylosing spondylitis.Semantic proximity Read ↗

Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo.Semantic proximity Read ↗

Structural and biochemical insights into the association between ERAP1 polymorphism and autoimmune diseases.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.Semantic proximity Read ↗

ERAP1: a potential therapeutic target for a myriad of diseasesSemantic proximity Read ↗

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view.Semantic proximity Read ↗

The role of polymorphic ERAP1 in autoinflammatory disease.Semantic proximity Read ↗

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: insights from genomic-wide association studies.Semantic proximity Read ↗

The Role of Aminopeptidase ERAP1 in Human Pathology—A ReviewSemantic proximity Read ↗

The Impact of the 'Mis-Peptidome' on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.