Article
Effect of DISC1 on the P300 waveform in psychosis.
Schizophrenia bulletin - 1 Jan 2013
Shaikh Madiha, Hall Mei-Hua, Schulze Katja, Dutt Anirban, Li Kuang, Williams Ian, Walshe Muriel, Constante Miguel, Broome Matthew, Picchioni Marco, Toulopoulou Timothea, Collier David, Stahl Daniel, Rijsdijk Fruhling, Powell John, Murray Robin M, Arranz Maria, Bramon Elvira
Abstract excerpt
INTRODUCTION: Abnormalities in the neurophysiological measures P300 amplitude and latency constitute endophenotypes for psychosis. Disrupted-in-Schizophrenia-1 (DISC1) has been proposed as a promising susceptibility gene for schizophrenia, and a previous study has suggested that it is associated with P300 deficits in schizophrenia. METHODS: We examined the role of variation in DISC1 polymorphisms on the P300...
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