Article
Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia.
PloS one - 1 Jan 2014
Rampino Antonio, Walker Rosie May, Torrance Helen Scott, Anderson Susan Maguire, Fazio Leonardo, Di Giorgio Annabella, Taurisano Paolo, Gelao Barbara, Romano Raffaella, Masellis Rita, Ursini Gianluca, Caforio Grazia, Blasi Giuseppe, Millar J Kirsty, Porteous David John, Thomson Pippa Ann, Bertolino Alessandro, Evans Kathryn Louise
Abstract excerpt
Cognitive dysfunction is central to the schizophrenia phenotype. Genetic and functional studies have implicated Disrupted-in-Schizophrenia 1 (DISC1), a leading candidate gene for schizophrenia and related psychiatric conditions, in cognitive function. Altered expression of DISC1 and DISC1-interactors has been identified in schizophrenia. Dysregulated expression of DISC1-interactome genes might, therefore,...
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