Article
The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia.
Psychiatry research - 30 Apr 2011
Chakirova Goultchira, Whalley Heather C, Thomson Pippa A, Hennah William, Moorhead Thomas W J, Welch Killian A, Giles Stephen, Hall Jeremy, Johnstone Eve C, Lawrie Stephen M, Porteous David J, Brown Verity J, McIntosh Andrew M
Abstract excerpt
Three risk variants (rs1538979, rs821577, and rs821633) in the Disrupted-in-Schizophrenia-1 (DISC1) gene have previously been associated with both schizophrenia and bipolar disorder in a recent collaborative analysis of European cohorts. In this study we examined the effects of these risk variants on brain activation during functional magnetic resonance imaging (fMRI) of the Hayling Sentence Completion Task...
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