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Article

Cryptococcus neoformans virulence gene discovery through insertional mutagenesis.

Eukaryotic cell - 1 Apr 2004

Idnurm Alexander, Reedy Jennifer L, Nussbaum Jesse C, Heitman Joseph

Abstract excerpt

Insertional mutagenesis was applied to Cryptococcus neoformans to identify genes associated with virulence attributes. Using biolistic transformation, we generated 4,300 nourseothricin (NAT)-resistant strains, of which 590 exhibited stable resistance. We focused on mutants with defects in established virulence factors and identified two with reduced growth at 37 degrees C, four with reduced production of the...

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Identifiers

PMID: 15075272
DOI: 10.1128/EC.3.2.420-429.2004
PMCID: PMC387659

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