Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans.

doi:10.1111/j.1365-2958.2005.04779.x

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Article

Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans.

Molecular microbiology - 1 Sept 2005

Walton Felicia J, Idnurm Alexander, Heitman Joseph

Abstract excerpt

The ability to produce melanin is a key virulence factor in many fungal pathogens including the human basidiomycete pathogen Cryptococcus neoformans, a major cause of life-threatening infections among immunocompromised persons. Despite the significance of melanin biosynthesis in virulence of C. neoformans, the cellular and molecular processes involved in this pathway have not yet been fully elucidated. Here, we...

Topics

Alleles
Base Sequence
Cation Transport Proteins
Chitin Synthase
Copper
Cryptococcus neoformans
Fungal Proteins
Genes, Fungal
Humans
Iron
Iron Chelating Agents
Laccase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanins

Molecular Sequence Data

Mutagenesis, Insertional

Mutation

Promoter Regions, Genetic

Rhizobium

Source

Open in PubMed

Identifiers

PMID: 16102007
DOI: 10.1111/j.1365-2958.2005.04779.x

Provenance

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