Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 Activation.

Oxidative medicine and cellular longevity - 1 Jan 2022

Chen Sixi, Bao Xinzhu, Chen Hongzhi, Jia Manli, Li Wen, Zhang Luyi, Fan Runxiao, Fang Hezhi, Jin Liqin

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations have been identified in various human cancers, including thyroid cancer. However, the relationship between mtDNA and thyroid cancer remains unclear. Previous studies by others and us strongly suggested that mtDNA mutations in complex I may participate in thyroid cancer processes according to sequencing results of thyroid cancer tissue, although the associated pathogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex I

Share to MAP Kinase Signaling System

Share to Mitochondrial Function and Pathology

Share to Mutation

Share to Reactive Oxygen Species

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 35464760
DOI: 10.1155/2022/9982449
PMCID: PMC9020963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 Activation.PMID 35464760Read ↗

Functional Role of Mitochondrial DNA in Cancer Progression.Semantic proximity Read ↗

High frequency of somatic mitochondrial DNA mutations in human thyroid carcinomas and complex I respiratory defect in thyroid cancer cell lines.Semantic proximity Read ↗

A Comprehensive Characterization of Mitochondrial Genome in Papillary Thyroid Cancer.Semantic proximity Read ↗

Deregulated Mitochondrial DNA in Diseases.Semantic proximity Read ↗

Somatic mitochondrial DNA mutations in human cancers.Semantic proximity Read ↗

Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.Semantic proximity Read ↗

The Mitochondrial DNA Control Region might have useful Diagnostic and Prognostic Biomarkers for Thyroid TumorsSemantic proximity Read ↗

The Significance of Mitochondrial Dysfunction in Cancer.Semantic proximity Read ↗

Spotlight on the relevance of mtDNA in cancer.Semantic proximity Read ↗

Comprehensive Molecular Characterization of Mitochondrial Genomes in Human CancersSemantic proximity Read ↗

Somatic mutations of mitochondrial DNA in aging and cancer progression.Semantic proximity Read ↗

Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.