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Article

Somatic mitochondrial DNA mutations in human cancers.

Advances in clinical chemistry - 1 Jan 2012

Yu Man

Abstract excerpt

Mitochondria are ubiquitous organelles in eukaryotic cells principally responsible for regulating cellular energy metabolism, free radical production, and the execution of apoptotic pathways. Abnormal oxidative phosphorylation (OXPHOS) and aerobic metabolism as a result of mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis. In the past decades, numerous somatic mutations in both...

Topics

Animals
Antineoplastic Agents
Cell Nucleus
DNA, Mitochondrial
Disease Progression
Humans
Mutation
Neoplasms
Receptor Cross-Talk

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22870588
DOI: 10.1016/b978-0-12-394384-2.00004-8

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