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Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma.

World journal of gastroenterology - 21 Dec 2013

Hsu Chia-Chi, Lee Hsin-Chen, Wei Yau-Huei

Abstract excerpt

Hepatocellular carcinoma (HCC) is one of the most common malignancies and is ranked third in mortality among cancer-related diseases. Mitochondria are intracellular organelles that are responsible for energy metabolism and cellular homeostasis, and mitochondrial dysfunction has been regarded as a hallmark of cancer. Over the past decades, several types of mitochondrial DNA (mtDNA) alterations have been identified...

Topics

Animals
Carcinoma, Hepatocellular
DNA Copy Number Variations
DNA, Mitochondrial
Disease Progression
Genetic Predisposition to Disease
Humans
Liver Neoplasms
Mitochondria, Liver
Mutation
Phenotype

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Identifiers

PMID: 24379611
DOI: 10.3748/wjg.v19.i47.8880
PMCID: PMC3870539

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