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Somatic mutations of mitochondrial DNA in aging and cancer progression.

Ageing research reviews - 1 Nov 2010

Lee Hsin-Chen, Chang Chia-Ming, Chi Chin-Wen

Abstract excerpt

Mitochondria are intracellular organelles responsible for generating ATP through respiration and oxidative phosphorylation (OXPHOS), producing reactive oxygen species, and initiating and executing apoptosis. Mitochondrial dysfunction has been observed to be an important hallmark of aging and cancer. Because mitochondrial DNA (mtDNA) is important in maintaining functionally competent organelles, accumulation of...

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PMID: 20816876
DOI: 10.1016/j.arr.2010.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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