Article
Spotlight on the relevance of mtDNA in cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Apr 2017
Cruz-Bermúdez A, Vicente-Blanco R J, Gonzalez-Vioque E, Provencio M, Fernández-Moreno M Á, Garesse R
Abstract excerpt
The potential role of the mitochondrial genome has recently attracted interest because of its high mutation frequency in tumors. Different aspects of mtDNA make it relevant for cancer's biology, such as it encodes a limited but essential number of genes for OXPHOS biogenesis, it is particularly susceptible to mutations, and its copy number can vary. Moreover, most ROS in mitochondria are produced by the electron...
Topics
- DNA, Mitochondrial
- Humans
- Mitochondria
- Mutation
- Neoplasms