Article
Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma.
Cancer cell - 13 Aug 2018
Gopal Raj K, Kübler Kirsten, Calvo Sarah E, Polak Paz, Livitz Dimitri, Rosebrock Daniel, Sadow Peter M, Campbell Braidie, Donovan Samuel E, Amin Salma, Gigliotti Benjamin J, Grabarek Zenon, Hess Julian M, Stewart Chip, Braunstein Lior Z, Arndt Peter F, Mordecai Scott, Shih Angela R, Chaves Frances, Zhan Tiannan, Lubitz Carrie C, Kim Jiwoong, Iafrate A John, Wirth Lori, Parangi Sareh, Leshchiner Ignaty, Daniels Gilbert H, Mootha Vamsi K, Dias-Santagata Dora, Getz Gad, McFadden David G
Abstract excerpt
Hürthle cell carcinoma of the thyroid (HCC) is a form of thyroid cancer recalcitrant to radioiodine therapy that exhibits an accumulation of mitochondria. We performed whole-exome sequencing on a cohort of primary, recurrent, and metastatic tumors, and identified recurrent mutations in DAXX, TP53, NRAS, NF1, CDKN1A, ARHGAP35, and the TERT promoter. Parallel analysis of mtDNA revealed recurrent homoplasmic...
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