Article
The Significance of Mitochondrial Dysfunction in Cancer.
International journal of molecular sciences - 5 Aug 2020
Luo Yongde, Ma Jianjia, Lu Weiqin
Abstract excerpt
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrial dysfunction, either due to the TCA cycle enzyme defects, mitochondrial DNA genetic mutations, defective mitochondrial electron transport chain, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been...
Topics
- Apoptosis
- DNA, Mitochondrial
- Energy Metabolism
- Humans
- Mitochondria
- Mutation
- Neoplasms
- Oxidation-Reduction
- Oxidative Stress