Article
Overdominant and partially dominant mutations drive clonal adaptation in diploid Saccharomyces cerevisiae.
Genetics - 31 May 2022
Aggeli Dimitra, Marad Daniel A, Liu Xianan, Buskirk Sean W, Levy Sasha F, Lang Gregory I
Abstract excerpt
Identification of adaptive targets in experimental evolution typically relies on extensive replication and genetic reconstruction. An alternative approach is to directly assay all mutations in an evolved clone by generating pools of segregants that contain random combinations of evolved mutations. Here, we apply this method to 6 Saccharomyces cerevisiae clones isolated from 4 diploid populations that were...
Topics
- Adaptation, Physiological
- Diploidy
- Genetic Fitness
- Haploidy
- Mutation
- Saccharomyces cerevisiae