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Article

Clonal Heterogeneity Influences the Fate of New Adaptive Mutations.

Cell reports - 17 Oct 2017

Vázquez-García Ignacio, Salinas Francisco, Li Jing, Fischer Andrej, Barré Benjamin, Hallin Johan, Bergström Anders, Alonso-Perez Elisa, Warringer Jonas, Mustonen Ville, Liti Gianni

Abstract excerpt

The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is poorly understood but essential to designing successful antimicrobial or cancer therapies. To address this, we evolve genetically diverse populations of budding yeast, S. cerevisiae, consisting of diploid cells with unique haplotype combinations. We study the asexual evolution of these populations under selective...

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Identifiers

PMID: 29045840
DOI: 10.1016/j.celrep.2017.09.046
PMCID: PMC5656752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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