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Article

Estimating the distribution of fitness effects of loss of heterozygosity (LOH) events using an engineered library of Saccharomyces cerevisiae.

PLoS genetics - 1 Mar 2026

Ke Yi-Hong, Orozco-Quime Michelle, Bauman Josh, Carvalho Tamilie, Landry Grant A, Ge Shuhua, Kumar Anuj, James Timothy Y

Abstract excerpt

Loss of heterozygosity (LOH) is a large contributor of genetic variation in natural populations or lab-evolved asexual diploids. However, its contribution to adaptation is uncertain, because the full spectrum of its fitness effects remains largely uncharacterized. To systematically investigate the distribution of fitness effects (DFE) of LOH, we engineered a diverse, barcoded library of heterozygous diploid...

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Identifiers

PMID: 41838761
DOI: 10.1371/journal.pgen.1012083
PMCID: PMC13016478

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