Article
Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast.
Cell - 8 Sept 2016
Venkataram Sandeep, Dunn Barbara, Li Yuping, Agarwala Atish, Chang Jessica, Ebel Emily R, Geiler-Samerotte Kerry, Hérissant Lucas, Blundell Jamie R, Levy Sasha F, Fisher Daniel S, Sherlock Gavin, Petrov Dmitri A
Abstract excerpt
Adaptive evolution plays a large role in generating the phenotypic diversity observed in nature, yet current methods are impractical for characterizing the molecular basis and fitness effects of large numbers of individual adaptive mutations. Here, we used a DNA barcoding approach to generate the...
Topics
- Adaptation, Physiological
- Diploidy
- Evolution, Molecular
- Genetic Fitness
- Genetic Techniques
- Genome, Fungal
- Genotype
- Haploidy
- Mutagenesis
- Mutation
- Saccharomyces cerevisiae