Article
High-Throughput Identification of Adaptive Mutations in Experimentally Evolved Yeast Populations.
PLoS genetics - 1 Oct 2016
Payen Celia, Sunshine Anna B, Ong Giang T, Pogachar Jamie L, Zhao Wei, Dunham Maitreya J
Abstract excerpt
High-throughput sequencing has enabled genetic screens that can rapidly identify mutations that occur during experimental evolution. The presence of a mutation in an evolved lineage does not, however, constitute proof that the mutation is adaptive, given the well-known and widespread phenomenon o...
Topics
- Adaptation, Physiological
- DNA Barcoding, Taxonomic
- Directed Molecular Evolution
- Genetic Fitness
- Genotype
- Mutation
- Saccharomyces cerevisiae
- Selection, Genetic