Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types from 10,983 cancer patients

Abstract excerpt

<h4>ABSTRACT</h4> Whole genome sequencing (WGS) allows exploration of the complete compendium of oncogenic processes generating characteristic patterns of mutations. Mutational signatures provide clues to tumour aetiology and highlight potentially targetable pathway defects. Here, alongside single base substitution (SBS), double base substitution (DBS), small insertions and deletions (ID) and copy number aberrati...

Topics

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• Chromosome Aberrations
• Databases, Nucleic Acid
• DNA Copy Number Variations
• Genome, Human
• Internet
• Mutation
• Neoplasms
• Whole Genome Sequencing

Identifiers and source

Literature Corpus work

d35d19d4-bec8-56ef-8467-50a742fbbfc5

DOI

10.1101/2023.06.07.23290970