Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids

Abstract excerpt

Uterine fibroid (UF) driver mutations in Mediator complex subunit 12 (MED12) trigger genomic instability and tumor development through unknown mechanisms. Herein, we show that MED12 mutations trigger aberrant R-loop-induced replication stress, suggesting a possible route to genomic instability and a novel therapeutic vulnerability in this dominant UF subclass. Immunohistochemical analyses of patient-matched...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endometriosis Research and Treatment
• Share to Gynecological conditions and treatments
• Share to Uterine Myomas and Treatments