Article

Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids

2026-01-13

Abstract excerpt

<title>Abstract</title> <p>Uterine fibroids (UFs) are the most important benign neoplastic threat to women’s health worldwide, with no long-term noninvasive treatment options currently available. Among known UF driver alterations, somatic mutations in Mediator subunit MED12 are by the far the most prevalent, accounting for up to 80% of these clinically significant lesions. Although it is presently unclear how MED...

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Literature Corpus work: a75b34c3-5231-599f-855a-40f7cef1923f
DOI: 10.21203/rs.3.rs-8031602/v1

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