Article

Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids

2025-09-18

Abstract excerpt

Uterine fibroids (UFs) are the most important benign neoplastic threat to women’s health worldwide, with no long-term noninvasive treatment options currently available. Among known UF driver alterations, somatic mutations in Mediator subunit MED12 are by the far the most prevalent, accounting for up to 80% of these clinically significant lesions. Although it is presently unclear how MED12 mutations trigger neoplas...

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Literature Corpus work: 68ab0ec8-aa77-5e7a-97dd-1f268c4e2db3
DOI: 10.1101/2025.09.17.676564

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