Article

Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogramming

2024-12-16

Abstract excerpt

<title>Abstract</title> <p>Uterine fibroids (UFs) are the most common non-cutaneous tumors in women worldwide. UFs arise from genetic alterations in myometrial stem cells (MM SCs) that trigger their transformation into tumor initiating cells (UF SCs). Mutations in the RNA polymerase II Mediator subunit MED12 are dominant drivers of UFs, accounting for 70% of these clinically significant lesions. Biochemically, UF...

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Literature Corpus work: fa7adc9c-53f0-5aba-b473-c353247b6a52
DOI: 10.21203/rs.3.rs-5125876/v1

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