Article

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization

2023-02-09

Abstract excerpt

<title>Abstract</title> <p>Uterine fibroid (UF) tumors originate from a mutated smooth muscle cell (SMC). Nearly 70% of these tumors are driven by hotspot recurrent somatic mutations in the <italic>MED12</italic> gene; however, there are no tractable genetic models to study the biology of UF tumors because, under culture conditions, the non-mutant fibroblasts outgrow the mutant SMC cells, resulting in the convers...

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Literature Corpus work: 4c119694-3a30-51cd-ba16-1f892ab03049
DOI: 10.21203/rs.3.rs-2537075/v1

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