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Tracking Somatic Mutations for Lineage Reconstruction.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2025

Neumeier Yaara, Raz Ofir, Tao Liming, Marx Zipora, Shapiro Ehud

Abstract excerpt

The human genome is composed of distinct genomic regions that are susceptible to various types of somatic mutations. Among these, Short Tandem Repeats (STRs) stand out as the most mutable genetic elements. STRs are short repetitive polymorphic sequences, predominantly situated within noncoding sectors of the genome. The intrinsic repetition characterizing these sequences makes them highly mutable in vivo....

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PMID: 39745634
DOI: 10.1007/978-1-0716-4310-5_2

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