Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry

8 Dec 2015

Abstract excerpt

Increasing evidence supports transcellular propagation of toxic protein aggregates, or proteopathic seeds, as a mechanism for the initiation and progression of pathology in several neurodegenerative diseases, including Alzheimer's disease and the related tauopathies. The potentially critical role of tau seeds in disease progression strongly supports the need for a sensitive assay that readily detects seeding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26710240
DOI: 10.3791/53205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitive Detection of Proteopathic Seeding Activity with FRET Flow CytometryPMID 26710240Read ↗

Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSFSemantic proximity Read ↗

Q-DOAS: A Proximity Quenching Assay for Real-Time Detection of Early Protein Aggregation EventsSemantic proximity Read ↗

Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer’s disease and primary age-related tauopathySemantic proximity Read ↗

Conformation Determines the Seeding Potencies of Native and Recombinant Tau AggregatesSemantic proximity Read ↗

Distinct alpha-synuclein strains derived from Parkinson’s disease patient tissues trigger differential inclusion pathology in a novel biosensor cell modelSemantic proximity Read ↗

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.Semantic proximity Read ↗

Sensitive detection and propagation of brain-derived tau assemblies in HEK293 based wild-type tau seeding assaysSemantic proximity Read ↗

Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of TauopathySemantic proximity Read ↗

VCP increases or decreases tau seeding using specific cofactorsSemantic proximity Read ↗

An automated workflow for quantifying the formation of synuclein aggregates in human dopaminergic neuronsSemantic proximity Read ↗

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.Semantic proximity Read ↗

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.