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Article

The Path to Therapeutic Furin Inhibitors: From Yeast Pheromones to SARS-CoV-2

22 Mar 2022

Abstract excerpt

The spurious acquisition and optimization of a furin cleavage site in the SARS-CoV-2 spike protein is associated with increased viral transmission and disease, and has generated intense interest in the development and application of therapeutic furin inhibitors to thwart the COVID-19 pandemic. This review summarizes the seminal studies that informed current efforts to inhibit furin. These include the convergent...

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PMID: 35408793
DOI: 10.3390/ijms23073435

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