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Article

The furin cleavage site is required for pathogenesis, but not transmission, of SARS-CoV-2.

Journal of virology - 22 Jul 2025

Morgan Angelica L, Vu Michelle N, Zhou Yiyang, Lokugamage Kumari G, Meyers William M, Alvarado R Elias, Ahearn Yani, Estes Leah K, Plante Jessica A, Johnson Bryan A, Suthar Mehul S, Walker David H, Plante Ken S, Menachery Vineet D

Abstract excerpt

The SARS-CoV-2 spike, key to viral entry, has two features that differentiate it from other sarbecoviruses: the presence of a furin cleavage site (FCS; PRRAR sequence) and an extended S1/S2 loop characterized by an upstream QTQTN amino acid motif. Our prior works show that shortening the S1/S2 loop by deleting either the FCS (ΔPRRA) or an upstream sequence (ΔQTQTN) ablates spike processing, alters host protease...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40492735
DOI: 10.1128/jvi.00467-25
PMCID: PMC12282137

Genes

TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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The furin cleavage site is required for pathogenesis, but not transmission, of SARS-CoV-2.PMID 40492735Read ↗

The furin cleavage site is required for pathogenesis, but not transmission of SARS-CoV-2Semantic proximity Read ↗

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QTQTN motif upstream of the furin-cleavage site plays key role in SARS-CoV-2 infection and pathogenesisSemantic proximity Read ↗

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.Semantic proximity Read ↗

The Emergence of the Spike Furin Cleavage Site in SARS-CoV-2Semantic proximity Read ↗

SARS-CoV-2 bearing a mutation at the S1/S2 cleavage site exhibits attenuated virulence and confers protective immunitySemantic proximity Read ↗

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