Article

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation

2021-02-05

Abstract excerpt

The SARS-CoV-2 coronavirus responsible for the global pandemic contains a unique furin cleavage site in the spike protein (S) that increases viral infectivity and syncytia formation. Here, we show that O-glycosylation near the furin cleavage site is mediated by specific members of the GALNT enzyme family and is dependent on the novel proline at position 681 (P681). We further demonstrate that O-glycosylation of S...

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Literature Corpus work: e8c7891f-714f-513c-8987-56db8ffadf4c
DOI: 10.1101/2021.02.05.429982

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