Article

The furin cleavage site is required for pathogenesis, but not transmission of SARS-CoV-2

2025-03-11

Abstract excerpt

The SARS-CoV-2 spike, key to viral entry, has two features that differentiate it from other sarbecoviruses: the presence of a furin cleavage site (FCS; PRRAR sequence) and an extended S1/S2 loop characterized by an upstream QTQTN amino acid motif. Our prior works show that shortening the S1/S2 loop by deleting either the FCS (ΔPRRA) or deleting an upstream sequence (ΔQTQTN), ablates spike processing, alters host p...

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Identifiers and source

Literature Corpus work: 68d92b43-ef04-5c31-8d1f-cf922f94ee1b
DOI: 10.1101/2025.03.10.642264

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