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Beyond Processing: Furin as a Central Hub in Viral Pathogenesis and Genetic Susceptibility.

Biomolecules - 30 Oct 2025

Silva-Ríos Adrián Alejandro, Mora-Ornelas Carlos Ernesto, Flores-Medina Luna Galilea, Muñoz-Valle José Francisco, Díaz-Palomera Carlos Daniel, García-Chagollan Mariel, Vizcaíno-Quirarte Alexis Missael, Viera-Segura Oliver

Abstract excerpt

Furin, a calcium-dependent serine endoprotease of the proprotein convertase family, plays a pivotal role in both physiological homeostasis and viral pathogenesis. By cleaving polybasic motifs within viral glycoproteins, furin enables the maturation of structural proteins essential for viral entry, fusion, and replication. This mechanism has been documented across a broad spectrum of human pathogens, including...

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COVID-19
Furin
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Internalization

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Identifiers

PMID: 41301448
DOI: 10.3390/biom15111530
PMCID: PMC12649860

Genes

FURIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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