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Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

28 Mar 2022

Abstract excerpt

SARS-CoV-2, the etiological agent of COVID-19, has so far resulted in >6.1 million deaths worldwide. The spike protein (S) of the virus directs infection of the lungs and other tissues by binding the angiotensin-converting enzyme 2 (ACE2) receptor. For effective infection, the S protein is cleaved at two sites: S1/S2 and S2'. Cleavage at S1/S2 induces a conformational change favoring the S protein recognition by...

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PMID: 35343766
DOI: 10.1128/jvi.00128-22

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