A second functional furin site in the SARS-CoV-2 spike protein.

doi:10.1080/22221751.2021.2014284

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Article

A second functional furin site in the SARS-CoV-2 spike protein.

Emerging microbes & infections - 1 Dec 2022

Zhang Yue, Zhang Li, Wu Jiajing, Yu Yuanling, Liu Shuo, Li Tao, Li Qianqian, Ding Ruxia, Wang Haixin, Nie Jianhui, Cui Zhimin, Wang Yulin, Huang Weijin, Wang Youchun

Abstract excerpt

The ubiquitously-expressed proteolytic enzyme furin is closely related to the pathogenesis of SARS-CoV-2 and therefore represents a key target for antiviral therapy. Based on bioinformatic analysis and pseudovirus tests, we discovered a second functional furin site located in the spike protein. Furin still increased the infectivity of mutated SARS-CoV-2 pseudovirus in 293T-ACE2 cells when the canonical polybasic...

Topics

Amino Acid Sequence
Angiotensin-Converting Enzyme 2
Animals
Cathepsin L
Cell Fusion
Chiroptera
Furin
Gene Expression
HEK293 Cells
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mutation

Receptors, Virus

SARS-CoV-2

Serine Endopeptidases

Spike Glycoprotein, Coronavirus

Vermilingua

Source

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Identifiers

PMID: 34856891
DOI: 10.1080/22221751.2021.2014284
PMCID: PMC8741242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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