Article

A yeast-based system to study SARS-CoV-2 M <sup>pro</sup> structure and to identify nirmatrelvir resistant mutations

2022-08-08

Abstract excerpt

The SARS-CoV-2 main protease (M pro ) is a major therapeutic target. The M pro inhibitor, nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID-19. As M pro inhibitor use increases, drug resistant mutations will likely emerge. We have established a non-pathogenic system, in which yeast growth serves as a proxy for M pro activity, enabling rapid identification of mutants...

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Literature Corpus work: 67d94a63-7884-57d1-87a3-5ae0ebeafe1f
DOI: 10.1101/2022.08.06.503039

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