Article

Functional and Multi-Omics Analysis of an Optimized CRISPR-Mediated FURIN Depletion in Cultured Pro-Monocytic Cells

2023-12-04

Abstract excerpt

The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious disease, cancer and cardiovascular disease. Previously, we performed a systemic inhibition of FURIN in a mouse model of atherosclerosis and demonstrated significant plaque reduction and alterations in macrophage function. To understand the cellular mechanisms affected by FURIN i...

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Literature Corpus work: 36d8604b-9ba2-59eb-ab19-230a52e24fb8
DOI: 10.20944/preprints202312.0178.v1

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