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Article

Game of clones: Battles in the field of carcinogenesis.

Pharmacology & therapeutics - 1 Sept 2022

Rahal Zahraa, Sinjab Ansam, Wistuba Ignacio I, Kadara Humam

Abstract excerpt

Recent advances in bulk sequencing approaches as well as genomic decoding at the single-cell level have revealed surprisingly high somatic mutational burdens in normal tissues, as well as increased our understanding of the landscape of "field cancerization", that is, molecular and immune alterations in mutagen-exposed normal-appearing tissues that recapitulated those present in tumors. Charting the somatic...

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Identifiers

PMID: 35850404
DOI: 10.1016/j.pharmthera.2022.108251
PMCID: PMC10249058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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