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Article

Somatic Mutations in Normal Tissues: Calm before the Storm.

Cancer discovery - 4 Apr 2024

Rahal Zahraa, Scheet Paul, Kadara Humam

Abstract excerpt

We explore the phenomenon of somatic mutations, including those in cancer driver genes, that are present in healthy, normal-appearing tissues and their potential implications for cancer development. We also examine the landscape of these somatic mutations, discuss the role of clonal cell competition and external factors like inflammation in enhancing the fitness of mutant clones, and conclude by considering how...

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Identifiers

PMID: 38571416
DOI: 10.1158/2159-8290.CD-23-1508
PMCID: PMC11234823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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