Article
Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight.
Journal of molecular medicine (Berlin, Germany) - 1 May 2022
Song Yu-Qian, Hu Shi-Di, Lin Xu, Meng Xiang-He, Wang Xiao, Zhang Yin-Hua, Peng Cheng, Gong Rui, Xu Tao, Zhang Tong, Li Chen-Zhong, Pan Dao-Yan, Yang Jia-Yi, Greenbaum Jonathan, Shen Jie, Deng Hong-Wen
Abstract excerpt
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify...
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