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Article

Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density.

BMC genomics - 25 Feb 2016

Mullin Benjamin H, Walsh John P, Zheng Hou-Feng, Brown Suzanne J, Surdulescu Gabriela L, Curtis Charles, Breen Gerome, Dudbridge Frank, Richards J Brent, Spector Tim D, Wilson Scott G

Abstract excerpt

BACKGROUND: Osteoporosis is a common and debilitating bone disease that is characterised by a low bone mineral density (BMD), a highly heritable trait. Genome-wide association studies (GWAS) have proven to be very successful in identifying common genetic variants associated with BMD adjusted for age, gender and weight, however a large portion of the genetic variance for this trait remains unexplained. There is...

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Source

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Identifiers

PMID: 26911590
DOI: 10.1186/s12864-016-2481-0
PMCID: PMC4766752

Genes

WLS
ESR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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