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Article

Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.

The Journal of clinical endocrinology and metabolism - 1 Jan 2018

Hu Yuan, Tan Li-Jun, Chen Xiang-Ding, Liu Zhen, Min Shi-Shi, Zeng Qin, Shen Hui, Deng Hong-Wen

Abstract excerpt

Context: Genome-wide association studies (GWASs) have been successful in identifying loci associated with osteoporosis and obesity. However, the findings explain only a small fraction of the total genetic variance. Objective: The aim of this study was to identify novel pleiotropic genes important in osteoporosis and obesity. Design and Setting: A pleiotropic conditional false discovery rate method was applied to...

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Share to Bone Density
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 29145611
DOI: 10.1210/jc.2017-01531
PMCID: PMC6061219

Genes

PUM1
JAG1
AKAP11
DNM3
MARK3
PRDM6
SPTBN1
TRPS1
XXYLT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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